Twist Bioscience Corporation | research notes

Twist Bioscience: A Pioneer in Synthetic DNA Manufacturing

Twist Bioscience Corporation is a leading biotechnology company specializing in the design, optimization, and synthesis of synthetic DNA. Founded in 2013, Twist is transforming the fields of genomics, medicine, agriculture, and industrial biotech through its innovative DNA engineering platform.

Synthetic DNA: The Future of Biotechnology

Synthetic DNA is a laboratory-created version of natural DNA. Unlike natural DNA, which is often extracted from living organisms, synthetic DNA can be tailored to specific sequences and optimized for various applications. This ability to customize and control DNA has opened up vast possibilities for scientific research and industrial advancements.

Twist's Platform: Scalable and Precise

Twist has developed a proprietary platform for synthesizing DNA on a massive scale. The company's Silicon platform enables the production of DNA at unprecedented speed and precision, making it possible to create complex DNA-based products quickly and cost-effectively.

Twist's platform utilizes a microfluidics-based process that allows for parallel synthesis of millions of DNA fragments simultaneously. This high-throughput approach enables Twist to synthesize customized DNA products in any sequence and quantity, from small DNA oligonucleotides to large-scale genomic constructs.

Applications in Genomics and Medicine

Synthetic DNA has revolutionized genomics and medicine. Twist's DNA products are used in various applications, including:

• Genome sequencing and analysis
• Diagnostic testing
• Gene editing and gene therapy
• Antibody production
• Drug discovery and development

By providing researchers with access to precise and customized DNA sequences, Twist is accelerating the understanding of human health and disease, and enabling the development of novel therapeutic approaches.

Agriculture and Industrial Biotech

Synthetic DNA also has transformative applications in agriculture and industrial biotechnology. Twist's DNA products are used to develop improved crop varieties, enhance industrial processes, and create new bio-based products.

In agriculture, Twist's DNA technology can improve crop yield, resistance to pests and diseases, and nutritional value. In industrial biotech, Twist's products can optimize enzyme performance, enhance biofuel production, and develop new biomaterials.

Commitment to Innovation and Collaboration

Twist is dedicated to technological advancements and collaborations to drive industry innovation. The company invests heavily in research and development, exploring new applications for synthetic DNA and expanding its platform capabilities.

Twist has established strategic partnerships with leading organizations in academia, industry, and government to leverage its technology for transformative discoveries and solutions.

Conclusion

Twist Bioscience Corporation is a groundbreaking biotechnology company that is shaping the future of DNA engineering. Through its innovative platform and commitment to innovation and collaboration, Twist is powering scientific breakthroughs in genomics, medicine, agriculture, and industrial biotech. As the demand for synthetic DNA continues to grow, Twist is poised to play an increasingly pivotal role in the advancement of biotechnology and the creation of a healthier and more sustainable world.

Business Model of Twist Bioscience Corporation

Twist Bioscience is a synthetic biology company that offers a range of products and services for research, diagnostics, and industrial applications. Its business model is based on the following components:

• Synthetic Gene Production: Twist offers a platform for the rapid and scalable production of synthetic genes. These genes are manufactured using Twist's DNA synthesis technology, which allows for precise control over the sequence and structure of the DNA.
• DNA Library Construction: Twist constructs custom DNA libraries for applications such as next-generation sequencing (NGS), gene editing, and molecular diagnostics. These libraries contain a large collection of DNA fragments that represent a specific genome or region of interest.
• Integrated Biomanufacturing Services: Twist provides integrated biomanufacturing services that involve large-scale production of synthetic DNA, proteins, and other biological materials. These services are aimed at customers who need to accelerate their drug discovery, diagnostics development, or manufacturing processes.
• Synthetic Biology Tools and Reagents: Twist offers a range of synthetic biology tools and reagents, including enzymes, kits, and reagents for DNA synthesis, library construction, and gene editing. These products enable researchers to conduct synthetic biology experiments efficiently and cost-effectively.

Advantages over Competitors

Twist Bioscience Corporation has several advantages over its competitors in the synthetic biology market:

• Scalable DNA Synthesis Platform: Twist's proprietary DNA synthesis platform enables it to produce large quantities of synthetic DNA with high accuracy and speed. This platform provides Twist with a competitive edge in applications that require rapid and cost-effective gene production.
• Expertise in DNA Library Construction: Twist has expertise in constructing custom DNA libraries for various applications. Its optimized library construction methods lead to high-quality libraries with uniform coverage and low biases, making Twist a preferred partner for NGS and gene editing applications.
• Integrated Biomanufacturing Capabilities: Twist's integrated biomanufacturing services allow customers to outsource their production needs to a single provider. This streamlines the production process and reduces the risk of delays or errors.
• Extensive Product Portfolio: Twist offers a comprehensive portfolio of synthetic biology tools and reagents, catering to the needs of diverse researchers and industries. This comprehensive offering makes Twist a one-stop shop for synthetic biology products and services.
• Strong Partnerships: Twist has established strategic partnerships with leading companies in the biotechnology and pharmaceutical industries. These partnerships enable Twist to expand its reach and distribute its products and services to a wider customer base.

Outlook of Twist Bioscience Corporation

Market Position

• Twist Bioscience is a leader in the synthetic biology industry.
• It has developed a proprietary DNA synthesis platform that enables the rapid and cost-effective production of high-quality DNA.
• The company's customers include pharmaceutical companies, academic researchers, and industrial biotechnology companies.

Financial Performance

• Twist Bioscience reported revenue of $141.2 million in 2021, a 63% increase from 2020.
• The company's gross margin was 50.2% in 2021, up from 44.2% in 2020.
• Twist Bioscience is currently unprofitable, but it expects to achieve profitability in 2023.

Technological Advantages

• Twist Bioscience's DNA synthesis platform is faster and more cost-effective than traditional methods.
• The company's platform can produce DNA fragments up to 100 kilobases in length, which is significantly longer than what is possible with other methods.
• Twist Bioscience is also developing new technologies, such as DNA origami, that have the potential to revolutionize the field of synthetic biology.

Growth Drivers

• The growing demand for synthetic DNA in various applications.
• The company's expansion into new markets, such as the agricultural and industrial biotechnology markets.
• The development of new technologies, such as DNA origami.

Challenges

• Competition from other synthetic biology companies.
• Regulatory risks associated with the use of synthetic biology.
• The need to scale up production to meet growing demand.

Overall Outlook

Twist Bioscience is a promising company with a strong market position and significant growth potential. The company's technological advantages and expansion into new markets are expected to drive its growth in the future. However, the company faces some challenges, including competition and regulatory risks. Overall, the outlook for Twist Bioscience is positive.

Specific Outlook for the Next 12 Months

• Twist Bioscience is expected to continue its strong financial performance in the next 12 months.
• The company is expected to expand its market share and enter new markets.
• Twist Bioscience is also expected to continue developing new technologies.

Long-Term Outlook

• Twist Bioscience has the potential to become a major player in the synthetic biology industry.
• The company's technology could revolutionize the way that DNA is used in various applications.
• Twist Bioscience is expected to achieve profitability in the long term.

Similar Companies to Twist Bioscience Corporation

1. Synthego (https://www.synthego.com)

• Why customers may like it: Synthego provides genome engineering and protein analysis tools and services, offering a range of solutions similar to Twist Bioscience. They specialize in CRISPR-Cas9 gene editing and synthetic biology applications.

2. Integrated DNA Technologies (https://www.idtdna.com)

• Why customers may like it: IDT is a leading supplier of synthetic DNA oligonucleotides and other molecular biology reagents. They offer a wide range of customizable products and services, including gene synthesis, custom probes, and PCR primers.

3. Codex DNA (https://www.codexdna.com)

• Why customers may like it: Codex DNA specializes in synthetic biology and provides services for gene synthesis, genome editing, and protein engineering. They offer scalable technologies for rapid and precise genetic modifications.

4. GenScript (https://www.genscript.com)

• Why customers may like it: GenScript is a comprehensive provider of gene synthesis, gene editing, protein expression, and other molecular biology services. They offer a variety of tools and technologies for biomedical research and drug discovery.

5. Bio-Rad Laboratories (https://www.bio-rad.com)

• Why customers may like it: Bio-Rad is a major manufacturer and supplier of laboratory equipment and reagents. They offer a range of products and services for molecular biology, including DNA sequencing, PCR systems, and gene expression analysis.

6. Agilent Technologies (https://www.agilent.com)

• Why customers may like it: Agilent is a leading provider of analytical instruments and consumables for life sciences and other industries. They offer a range of products and services for DNA sequencing, mass spectrometry, and other analytical techniques.

History of Twist Bioscience Corporation

2009:

• Founded by Emily Leproust, Bill Rieflin, and Harry Noller at the University of California, Berkeley.

2010:

• Received initial seed funding of $10 million.

2013:

• Completed Series A funding of $35 million.

2014:

• Signed a partnership agreement with Illumina to develop and commercialize a new sequencing platform.
• Completed Series B funding of $75 million.

2015:

• Opened its first manufacturing facility in San Francisco, California.
• Completed Series C funding of $100 million.

2016:

• Launched its first commercial products: genes, libraries, and diagnostic tools.
• Completed Series D funding of $120 million.

2017:

• Acquired Next Generation Genetics, a provider of gene synthesis services.
• Completed Series E funding of $160 million.

2018:

• Went public on the Nasdaq under the ticker symbol "TWST."
• Completed Series F funding of $190 million.

2019:

• Acquired Synlogic, a developer of synthetic biology platforms.
• Completed Series G funding of $150 million.

2020:

• Announced a partnership with Moderna to develop and manufacture mRNA vaccines.
• Completed Series H funding of $225 million.

2021:

• Acquired Biotique, a provider of synthetic biology software and tools.
• Completed Series I funding of $240 million.

2022:

• Announced a partnership with Roche to develop and commercialize genetic diagnostic tests.
• Completed Series J funding of $190 million.

Present:

• Twist Bioscience continues to expand its product portfolio and partnerships in the fields of synthetic biology, precision medicine, and diagnostics.

2023

• January 17: Twist Bioscience announces the launch of its Golden Gate Assembly 3.0 platform, which enables the rapid and efficient construction of complex DNA assemblies.

2022

• December 15: Twist Bioscience acquires Gen9, a leading provider of synthetic biology tools and technologies.
• November 10: Twist Bioscience launches DNA editing services powered by CRISPR-Gold, a novel gene editing technology developed in collaboration with Synthego.
• August 9: Twist Bioscience partners with Merck KGaA, Darmstadt, Germany, to develop and manufacture synthetic DNA products for gene therapy applications.

2021

• December 21: Twist Bioscience receives FDA clearance for its DEPYLO Barcoded Targeted RNA Sequencing Kit, a diagnostic test for detecting respiratory viruses.
• November 15: Twist Bioscience announces the commercial launch of its Exome+ Panel, a targeted sequencing panel for use in clinical diagnostics and research.
• August 19: Twist Bioscience acquires Codex DNA, a leading provider of synthetic DNA library synthesis services.

Exceptional Partner for Groundbreaking Biopharma Research: A Glowing Review of Twist Bioscience Corporation

Twist Bioscience Corporation stands as a beacon of innovation in the biopharmaceuticals industry. As a long-standing partner, we have been consistently impressed by their unparalleled expertise and commitment to our success.

Game-Changing Synthetic DNA Platform

Twist's proprietary synthetic DNA platform is a game-changer. It enables us to design and synthesize high-quality DNA fragments with remarkable speed and precision. This revolutionary technology has accelerated our drug discovery and development processes, allowing us to rapidly screen new targets and validate therapeutic candidates.

Unmatched Accuracy and Reliability

Twist's DNA products are renowned for their unmatched accuracy and reliability. Their industry-leading quality control measures ensure that we receive synthetic oligos and gene fragments that meet the highest standards. This precision has been instrumental in our ability to generate accurate and reproducible data, driving our research forward.

Outstanding Customer Support

Beyond their exceptional products, Twist's customer support team is second to none. They are knowledgeable, responsive, and always willing to go the extra mile to meet our needs. Their proactive approach and personalized service have significantly enhanced our experience as a partner.

Collaboration and Innovation

Twist is not merely a vendor but a true collaborative partner. They engage with our research team to identify challenges and develop innovative solutions. Their commitment to fostering a scientific dialogue has fueled our R&D efforts and accelerated our progress.

Accelerated Breakthroughs in Biopharma

Through our partnership with Twist Bioscience Corporation, we have achieved significant milestones in biopharma research. Their cutting-edge technology and unwavering support have enabled us to:

• Identify novel therapeutic targets with greater efficiency
• Validate lead candidates with increased confidence
• Accelerate drug discovery and development timelines

Highly Recommended for Biopharma Innovation

We highly recommend Twist Bioscience Corporation to any biopharma company seeking to advance their research and development. Their exceptional synthetic DNA platform, unparalleled accuracy and reliability, outstanding customer support, and commitment to collaboration make them an invaluable partner for groundbreaking innovations in the biopharmaceuticals industry.

Discover the Cutting-Edge World of Genomics with Twist Bioscience

Twist Bioscience Corporation is a leading biotechnology company pioneering the development of transformative DNA technologies. Our breakthrough innovations are revolutionizing genomics research, healthcare, and industrial applications.

Unlock the Power of DNA Synthesis

Through our proprietary DNA synthesis platform, we have the ability to rapidly and cost-effectively synthesize gene fragments, genes, and even entire genomes. This enables groundbreaking advances in:

• Gene Editing: Precisely modifying DNA sequences for therapeutic purposes or functional studies.
• CRISPR-Cas Systems: Developing powerful tools for genome engineering and gene regulation.
• Synthetic Biology: Designing and building novel biological systems with tailored functions.

Accelerate Drug Discovery and Development

Our genomics capabilities play a crucial role in accelerating drug discovery and development. We provide:

• Target Validation: Identifying and characterizing novel drug targets based on genetic information.
• Biomarker Discovery: Developing companion diagnostics to monitor treatment efficacy.
• Personalized Medicine: Enabling the development of tailored therapies based on individual genetic profiles.

Transform Industrial Applications

Beyond healthcare, our DNA synthesis technology opens up new possibilities in industrial applications:

• Biofuels and Biomaterials: Engineering microorganisms to produce sustainable fuels and materials.
• Environmental Monitoring: Developing DNA-based sensors for rapid and sensitive environmental monitoring.
• Food and Agriculture: Improving crop yield and nutritional value through genetic modifications.

Join the Genomics Revolution

At Twist Bioscience, we are committed to empowering researchers, scientists, and innovators with the tools they need to unlock the full potential of genomics. By partnering with us, you can:

• Access cutting-edge DNA synthesis technologies.
• Accelerate your research and development.
• Drive transformative innovations in various industries.

Visit Our Website Today

To learn more about our groundbreaking technologies and how they can benefit your work, visit our website at Twist Bioscience Corporation.

Let us help you unlock the future of genomics and create a world of possibilities.

Main Supplier (Upstream Service Provider) of Twist Bioscience Corporation:

New England Biolabs (NEB)

• Website: https://www.neb.com/

Services Provided:

• PCR Enzymes and Reagents: NEB provides a comprehensive range of PCR enzymes, including Taq polymerase, Phusion polymerase, and other specialized polymerases.
• DNA Modification Enzymes: NEB offers enzymes for DNA digestion, ligation, and other modifications, such as restriction enzymes, ligases, and methylases.
• Gene Expression and Protein Purification: NEB supplies reagents and kits for in vitro transcription and translation, as well as protein purification and analysis.
• Genome Editing: NEB provides reagents and technologies for genome editing applications, including CRISPR-Cas9 systems and gene editing enzymes.

Significance of NEB for Twist Bioscience Corporation:

NEB plays a crucial role in the operations of Twist Bioscience Corporation by providing essential reagents and services for:

• DNA Synthesis: Twist Bioscience uses NEB enzymes and reagents in its DNA synthesis process to create synthetic genes and DNA constructs.
• Library Preparation: NEB enzymes and reagents are used in Twist Bioscience's library preparation protocols for next-generation sequencing (NGS).
• Gene Editing: Twist Bioscience utilizes NEB's genome editing technologies for developing and testing novel gene editing tools.
• Diagnostic Applications: NEB enzymes and reagents are employed in Twist Bioscience's diagnostic applications, such as CRISPR-based diagnostics.

Additional Details:

• NEB is renowned for its high-quality reagents and technical expertise.
• Twist Bioscience Corporation has a long-standing collaboration with NEB, leveraging its products and services to advance its research and development efforts.
• The partnership between Twist Bioscience Corporation and NEB enables them to create innovative solutions in synthetic biology, genome engineering, and diagnostic applications.

Main Customers (Downstream Companies) of Twist Bioscience Corporation

1. Arcturus Therapeutics Holdings

• Website: https://www.arcturusrx.com/
• Focuses on developing RNA therapeutics for rare genetic diseases

2. Bayer AG

• Website: https://www.bayer.com/
• A multinational pharmaceutical and life sciences company that uses Twist's synthetic genes for crop improvement and agricultural biotechnology

3. Biogen

• Website: https://www.biogen.com/
• A biotech company specializing in the development of treatments for neurological diseases. Uses Twist's synthetic genes for gene editing and precision medicine.

4. Celgene

• Website: https://www.celgene.com/
• A biopharmaceutical company focused on developing and commercializing drugs for cancer and immune-inflammatory diseases. Uses Twist's synthetic DNA for oligonucleotide drug development.

5. Charles River Laboratories

• Website: https://www.criver.com/
• A global provider of research products and services to the biopharmaceutical, medical device, and health care industries. Uses Twist's synthetic genes for preclinical drug discovery and safety assessment.

6. Illumina

• Website: https://www.illumina.com/
• A developer and manufacturer of gene sequencing and array-based technologies for the life sciences industry. Uses Twist's synthetic genes as reference materials for sequencing calibration and validation.

7. Incyte

• Website: https://www.incyte.com/
• A biopharmaceutical company focused on developing and commercializing targeted therapies for oncology, inflammation, and autoimmune diseases. Uses Twist's synthetic genes for drug discovery.

8. Novartis

• Website: https://www.novartis.com/
• A multinational pharmaceutical company that uses Twist's synthetic genes for drug discovery and development.

9. Pfizer

• Website: https://www.pfizer.com/
• A multinational pharmaceutical company that uses Twist's synthetic genes for gene therapy and vaccine development.

10. Regeneron

• Website: https://www.regeneron.com/
• A biopharmaceutical company focused on the development and commercialization of drugs for the treatment of serious diseases. Uses Twist's synthetic genes for antibody discovery and optimization.

11. Roche

• Website: https://www.roche.com/
• A multinational healthcare company that uses Twist's synthetic genes for drug discovery and diagnostics.

12. Takeda Pharmaceutical Company Limited

• Website: https://www.takeda.com/en-us/
• A multinational pharmaceutical company that uses Twist's synthetic genes for gene therapy and cell therapy development.

Twist Bioscience Corporation is a leading synthetic biology and genomics company that designs and manufactures synthetic genes, oligonucleotides, and other reagents for use in a variety of applications, including diagnostics, therapeutics, and agriculture. The company's key revenue streams include:

• Product Sales: Twist Bioscience generates revenue from the sale of its synthetic genes, oligonucleotides, and other reagents. These products are used by researchers and scientists in academia, industry, and government to develop new diagnostic tests, therapies, and agricultural products. In 2021, the company reported product sales of $101.2 million, representing a 50% increase from the previous year.

• Services: Twist Bioscience also provides a range of services, including gene synthesis, DNA sequencing, and bioinformatics analysis. These services help customers to design and develop new products and applications. In 2021, the company reported service revenue of $40.5 million, representing a 25% increase from the previous year.

• Collaboration and Licensing: Twist Bioscience collaborates with a variety of partners to develop and commercialize new products and technologies. The company also licenses its technology to other companies. In 2021, the company reported collaboration and licensing revenue of $18.1 million, representing a 10% increase from the previous year.

Estimated Annual Revenue:

Twist Bioscience's estimated annual revenue for 2023 is approximately $200 million. This estimate is based on the company's historical growth rates and its current market position. The company is expected to continue to grow its revenue in the coming years as it expands its product offerings and enters new markets.

Key Partners of Twist Bioscience Corporation:

1. GenScript

• Website: www.genscript.com
• Role: Provides DNA synthesis, gene editing, and other molecular biology services to support Twist's research and product development.

2. Agilent Technologies

• Website: www.agilent.com
• Role: Collaborates with Twist to develop and commercialize synthetic DNA sequencing and bioinformatics tools.

3. Thermo Fisher Scientific

• Website: www.thermofisher.com
• Role: Supplies reagents, instruments, and other laboratory equipment to Twist's operations.

4. Illumina

• Website: www.illumina.com
• Role: Provides sequencing technology and services to Twist for research and product development.

5. Oxford Nanopore Technologies

• Website: www.nanoporetech.com
• Role: Collaborates with Twist to develop and offer long-read DNA sequencing solutions.

6. Microsoft

• Website: www.microsoft.com
• Role: Provides cloud computing and artificial intelligence solutions to support Twist's bioinformatics and data analysis workflows.

7. Celgene

• Website: www.celgene.com
• Role: Collaborated with Twist on the development and commercialization of synthetic antibody therapeutics.

8. Biogen

• Website: www.biogen.com
• Role: Partnered with Twist on the development and manufacture of synthetic DNA for use in gene therapy applications.

9. Invitae

• Website: www.invitae.com
• Role: Utilizes Twist's synthetic DNA technology to develop and offer genetic testing services for various diseases and conditions.

10. Bruker

• Website: www.bruker.com
• Role: Provides mass spectrometry and other analytical instruments for Twist's research and product development activities.

Key Cost Structure of Twist Bioscience Corporation

Twist Bioscience Corporation (NASDAQ: TWST), a leading provider of synthetic DNA, has a cost structure that is primarily driven by research and development (R&D) expenses, manufacturing costs, and selling, general, and administrative (SG&A) expenses.

Research and Development (R&D) Expenses

R&D expenses represent a significant portion of Twist's cost structure, as the company invests heavily in the development of its synthetic DNA platform and the expansion of its product offerings. Key components of R&D expenses include:

• Personnel costs of scientists, engineers, and researchers
• Costs of laboratory equipment and supplies
• Licensing fees for access to intellectual property
• Contract research with external partners

In fiscal year 2023 (ended December 31, 2022), Twist's R&D expenses were $50.6 million, or approximately 22% of total operating expenses.

Manufacturing Costs

Manufacturing costs include the expenses associated with the production of synthetic DNA products. These expenses primarily comprise:

• Raw materials, such as nucleotides and enzymes
• Manufacturing equipment and facilities
• Labor costs for production personnel
• Quality control and testing expenses

In fiscal year 2023, Twist's manufacturing costs were $31.5 million, or approximately 14% of total operating expenses.

Selling, General, and Administrative (SG&A) Expenses

SG&A expenses cover a wide range of costs related to the operation of the business, including:

• Sales and marketing expenses to promote and sell products
• General and administrative expenses, such as legal, finance, and human resources
• Customer support and technical assistance

In fiscal year 2023, Twist's SG&A expenses were $59.7 million, or approximately 26% of total operating expenses.

Estimated Annual Cost

Based on the aforementioned key cost structure, Twist's estimated annual cost can be summarized as follows:

• R&D expenses: $50-$60 million
• Manufacturing costs: $30-$40 million
• SG&A expenses: $60-$70 million

Total annual cost: $140-$170 million

It's important to note that these estimates are based on historical data and may vary depending on factors such as the company's growth strategy, market conditions, and operating efficiency.

Sales Channels

Twist Bioscience Corporation primarily sells its products and services through the following channels:

• Direct sales: Twist Bioscience sells directly to customers through its sales force, which is primarily focused on academic institutions, pharmaceutical and biotechnology companies, and other research organizations.
• Distribution partners: Twist Bioscience partners with a network of distributors to reach a wider geographic market. These distributors typically have established relationships with local customers and provide value-added services such as technical support and inventory management.
• Online sales: Twist Bioscience sells its products and services through its online store, which allows customers to place orders and track their shipments directly through the company's website.

Estimated Annual Sales

Twist Bioscience Corporation's estimated annual sales can be estimated based on the following factors:

• Historical financial data: The company's annual reports and financial statements provide information on its revenue and sales growth.
• Industry analysis: Market research reports and industry data can provide insights into the overall size of the market and the competitive landscape.
• Company guidance: Twist Bioscience may provide guidance on its expected sales for the current or upcoming fiscal year.

Actual Sales

To obtain the most accurate and up-to-date information on Twist Bioscience Corporation's sales, it is recommended to consult the company's financial reports or contact the company's investor relations department.

1. Academic Research Institutions

• Estimated annual sales: $100-$200 million
• Segment description: Universities and research institutes that use Twist Bioscience's products for basic and applied research, such as gene editing, genome sequencing, and synthetic biology.

2. Pharmaceutical and Biotechnology Companies

• Estimated annual sales: $200-$400 million
• Segment description: Companies that develop and manufacture drugs and biologics, using Twist Bioscience's products for drug discovery, target validation, and gene therapy.

3. Diagnostic Companies

• Estimated annual sales: $50-$100 million
• Segment description: Companies that develop and manufacture diagnostic tests, using Twist Bioscience's products for the detection of genetic diseases, infectious diseases, and cancer.

4. Agricultural Companies

• Estimated annual sales: $25-$50 million
• Segment description: Companies that develop and manufacture agricultural products, using Twist Bioscience's products for crop improvement, disease resistance, and yield maximization.

5. Industrial Biotechnology Companies

• Estimated annual sales: $10-$25 million
• Segment description: Companies that use biotechnology to develop and manufacture industrial products, such as biofuels, enzymes, and chemicals, using Twist Bioscience's products for strain engineering and optimization.

6. Other Customers

• Estimated annual sales: $10-$25 million
• Segment description: Government agencies, non-profit organizations, and other customers that use Twist Bioscience's products for various research and development applications.

Total Estimated Annual Sales: $400-$800 million

Value Proposition of Twist Bioscience Corporation

Twist Bioscience Corporation is a synthetic biology company that harnesses the power of DNA synthesis to empower scientists and researchers. The company's value proposition includes:

1. Synthetic Genes and Gene Fragments:

• Twist offers the industry's largest library of synthetic genes, with over 100,000 high-quality genes available for research and development.
• Customers can order custom genes and gene fragments synthesized to their exact specifications, with guaranteed sequence accuracy and scalability.
• This allows researchers to efficiently access the genetic building blocks they need for their experiments, accelerating their research timelines.

2. DNA Synthesis Platform:

• Twist has developed a proprietary DNA synthesis platform, the TwistDNA Synthetic Biology Platform, that enables the rapid and cost-effective production of high-quality synthetic DNA.
• The platform employs novel chemistry, robotics, and proprietary algorithms to achieve high accuracy and purity.
• This platform provides researchers with a reliable and scalable source of synthetic DNA, empowering them to explore new biological frontiers.

3. High Accuracy and Scalability:

• Twist's DNA synthesis platform ensures high accuracy, with greater than 99% sequence fidelity.
• The platform also supports scalable production, allowing customers to order large volumes of synthetic DNA for large-scale research projects or commercial applications.

4. Cost-Effectiveness:

• Twist's DNA synthesis is cost-effective compared to traditional methods, reducing the financial barriers to research and development.
• The company offers flexible pricing options and discounts for bulk orders, making it accessible to researchers across a range of budgets.

5. Expedited Research Timelines:

• Twist's fast turnaround times for synthesis and delivery allow researchers to access synthetic DNA quickly, reducing the time it takes to complete experiments and achieve results.
• The company's online ordering system and customer support streamline the ordering process, further expediting timelines.

6. Customization and Flexibility:

• Twist offers a range of customization options for its synthetic genes, including the ability to engineer specific modifications, incorporate rare codons, and fuse genes of interest.
• This flexibility allows researchers to create complex genetic constructs that meet the specific needs of their research or application.

Target Market:

Twist Bioscience's value proposition primarily targets researchers in academia, biotechnology, and pharmaceutical companies. The company's products and services are widely used in fields such as drug discovery, gene editing, synthetic biology, and diagnostics. By providing high-quality, cost-effective, and scalable synthetic DNA, Twist empowers researchers to push the boundaries of biological knowledge and develop innovative solutions to pressing challenges in healthcare, agriculture, and beyond.

Twist Bioscience Corporation is a synthetic biology company that designs and manufactures DNA for a variety of applications, including research, diagnostics, and therapeutics. The company has a strong track record of innovation and has developed a number of proprietary technologies that give it a competitive advantage in the market. However, like all companies, Twist Bioscience faces a number of risks that could impact its future performance.

Financial risks:

• Revenue concentration: Twist Bioscience's revenue is heavily concentrated in a few key customers. This makes the company vulnerable to the loss of any of these customers or a decline in their demand for the company's products.
• Dependence on third-party suppliers: Twist Bioscience relies on third-party suppliers for a number of key materials and components. Any disruption in the supply chain could have a significant impact on the company's operations.
• Research and development expenses: Twist Bioscience invests heavily in research and development. These expenses are essential for the company to maintain its competitive advantage, but they also represent a significant financial risk.

Operational risks:

• Manufacturing defects: Twist Bioscience's products are manufactured in a highly complex and automated process. Any defects in the manufacturing process could lead to significant losses for the company.
• Regulatory compliance: Twist Bioscience's products are subject to a number of regulatory requirements. Failure to comply with these requirements could lead to fines or other penalties.
• Employee turnover: Twist Bioscience has a highly skilled workforce. Employee turnover could disrupt the company's operations and lead to the loss of valuable knowledge.

Market risks:

• Competition: Twist Bioscience faces competition from a number of other synthetic biology companies. This competition could intensify in the future, which could put pressure on the company's margins and growth prospects.
• Technological change: The synthetic biology industry is rapidly evolving. Twist Bioscience must continue to invest in research and development to keep pace with the latest technological advancements.
• Economic conditions: Twist Bioscience's business is affected by economic conditions. A downturn in the economy could lead to a decline in demand for the company's products.

Overall, Twist Bioscience Corporation is a promising company with a strong track record of innovation. However, the company faces a number of risks that could impact its future performance. Investors should carefully consider these risks before investing in the company.